Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state

@inproceedings{Zhang2018CrystalSO,
  title={Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state},
  author={Xi Tian Zhang and Qifan Wang and Jianping Wu and Jiawei Wang and Yigong Shi and Minhao Liu},
  booktitle={Proceedings of the National Academy of Sciences of the United States of America},
  year={2018}
}
Lysyl oxidases (LOXs), a type of copper- and lysyl tyrosylquinone (LTQ) -dependent amine oxidase, catalyze the oxidative deamination of lysine residues of extracellular matrix (ECM) proteins such as elastins and collagens and generate aldehyde groups. The oxidative deamination of lysine represents the foundational step for the cross-linking of elastin and collagen and thus is crucial for ECM modeling. Despite their physiological significance, the structure of this important family of enzymes… CONTINUE READING
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