Crystal structure of human homogentisate dioxygenase


Homogentisate dioxygenase (HGO) cleaves the aromatic ring during the metabolic degradation of Phe and Tyr. HGO deficiency causes alkaptonuria (AKU), the first human disease shown to be inherited as a recessive Mendelian trait. Crystal structures of apo-HGO and HGO containing an iron ion have been determined at 1.9 and 2.3 Å resolution, respectively. The HGO… (More)
DOI: 10.1038/76756


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@article{Titus2000CrystalSO, title={Crystal structure of human homogentisate dioxygenase}, author={Greg P. Titus and Heather A. Mueller and John Burgner and Santiago Rodr{\'i}guez C de C{\'o}rdoba and Miguel A Pe{\~n}alva and David E. Timm}, journal={Nature Structural Biology}, year={2000}, volume={7}, pages={542-546} }