Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.

@article{Jia2000CrystalSO,
  title={Crystal structure of human grancalcin, a member of the penta-EF-hand protein family.},
  author={Jia Jia and Qing Han and Neils Borregaard and Karsten Lollike and Miroslaw Cygler},
  journal={Journal of molecular biology},
  year={2000},
  volume={300 5},
  pages={1271-81}
}
Grancalcin is a Ca(2+)-binding protein expressed at high level in neutrophils. It belongs to the PEF family, proteins containing five EF-hand motifs and which are known to associate with membranes in Ca(2+)-dependent manner. Prototypic members of this family are Ca(2+)-binding domains of calpain. Our recent finding that grancalcin interacts with L-plastin, a protein known to have actin bundling activity, suggests that grancalcin may play a role in regulation of adherence and migration of… CONTINUE READING