Crystal structure of human adenovirus at 3.5 A resolution.

@article{Reddy2010CrystalSO,
  title={Crystal structure of human adenovirus at 3.5 A resolution.},
  author={V. Sivaprasad Reddy and S. Kundhavai Natchiar and Phoebe L. Stewart and Glen R. Nemerow},
  journal={Science},
  year={2010},
  volume={329 5995},
  pages={1071-5}
}
Rational development of adenovirus vectors for therapeutic gene transfer is hampered by the lack of accurate structural information. Here, we report the x-ray structure at 3.5 angstrom resolution of the 150-megadalton adenovirus capsid containing nearly 1 million amino acids. We describe interactions between the major capsid protein (hexon) and several accessory molecules that stabilize the capsid. The virus structure also reveals an altered association between the penton base and the trimeric… CONTINUE READING
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