Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.

  title={Crystal structure of human T cell leukemia virus protease, a novel target for anticancer drug design.},
  author={Mi Li and Gary S. Laco and Mariusz Jask{\'o}lski and Jan Rozycki and Jerry N Alexandratos and Alexander Wlodawer and Alla Gustchina},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={102 51},
The successful development of a number of HIV-1 protease (PR) inhibitors for the treatment of AIDS has validated the utilization of retroviral PRs as drug targets and necessitated their detailed structural study. Here we report the structure of a complex of human T cell leukemia virus type 1 (HTLV-1) PR with a substrate-based inhibitor bound in subsites P5 through P5'. Although HTLV-1 PR exhibits an overall fold similar to other retroviral PRs, significant structural differences are present in… CONTINUE READING
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