Crystal structure of human IPS-1/MAVS/VISA/Cardif caspase activation recruitment domain

Abstract

IPS-1/MAVS/VISA/Cardif is an adaptor protein that plays a crucial role in the induction of interferons in response to viral infection. In the initial stage of the intracellular antiviral response two RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation-association gene 5 (MDA5), are independently able to bind viral RNA in the… (More)
DOI: 10.1186/1472-6807-8-11

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