Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.

  title={Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.},
  author={Stacie L. Bulfer and Jenna M. Hendershot and Raymond C Trievel},
  volume={80 2},
Homoisocitrate dehydrogenase (HICDH) catalyzes the conversion of homoisocitrate to 2-oxoadipate, the third enzymatic step in the α-aminoadipate pathway by which lysine is synthesized in fungi and certain archaebacteria. This enzyme represents a potential target for anti-fungal drug design. Here, we describe the first crystal structures of a fungal HICDH, including structures of an apoenzyme and a binary complex with a glycine tri-peptide. The structures illustrate the homology of HICDH with… CONTINUE READING

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Showing 1-10 of 27 references

CHAINSAW: a program for mutating pdb files used as templates in molecular replacement

N. Stein
J Appl Crystallogr • 2008

Coot: model-building tools for molecular graphics.

Acta crystallographica. Section D, Biological crystallography • 2004

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