Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.

@article{Bulfer2012CrystalSO,
  title={Crystal structure of homoisocitrate dehydrogenase from Schizosaccharomyces pombe.},
  author={Stacie L. Bulfer and Jenna M. Hendershot and Raymond C Trievel},
  journal={Proteins},
  year={2012},
  volume={80 2},
  pages={661-6}
}
Homoisocitrate dehydrogenase (HICDH) catalyzes the conversion of homoisocitrate to 2-oxoadipate, the third enzymatic step in the α-aminoadipate pathway by which lysine is synthesized in fungi and certain archaebacteria. This enzyme represents a potential target for anti-fungal drug design. Here, we describe the first crystal structures of a fungal HICDH, including structures of an apoenzyme and a binary complex with a glycine tri-peptide. The structures illustrate the homology of HICDH with… CONTINUE READING

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