Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.

@article{Chen1992CrystalSO,
  title={Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy.},
  author={Pojen P. Chen and Ursula Schulze-Gahmen and Enrico A Stura and James Inglese and Dana L. Johnson and Ariane E. Marolewski and Stephen J Benkovic and Ian A. Wilson},
  journal={Journal of molecular biology},
  year={1992},
  volume={227 1},
  pages={283-92}
}
The atomic structure of glycinamide ribonucleotide transformylase, an essential enzyme in purine biosynthesis, has been determined at 3.0 A resolution. The last three C-terminal residues and a sequence stretch of 18 residues (residues 113 to 130) are not visible in the electron density map. The enzyme forms a dimer in the crystal structure. Each monomer is divided into two domains, which are connected by a central mainly parallel seven-stranded beta-sheet. The N-terminal domain contains a… CONTINUE READING