Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites.

@article{Fujihashi2003CrystalSO,
  title={Crystal structure of fucose-specific lectin from Aleuria aurantia binding ligands at three of its five sugar recognition sites.},
  author={Masahiro Fujihashi and Diane Hope Peapus and Nobuo Kamiya and Yoshiho Nagata and Kunio Miki},
  journal={Biochemistry},
  year={2003},
  volume={42 38},
  pages={11093-9}
}
Aleuria aurantia possesses a fucose-specific lectin (AAL) that is widely used as a specific probe for fucose. Fucosylated sugars often play pivotal roles in many cellular processes. We have determined the crystal structure of AAL at 2.24 A resolution in complex with only three fucose molecules in its five sugar binding sites of a six-fold beta-propeller structure. Very recently, the structure of AAL has been independently determined, showing that all the five binding sites were occupied by… CONTINUE READING

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