Crystal structure of enterotoxigenic Escherichia coli colonization factor CS6 reveals a novel type of functional assembly.

@article{Roy2012CrystalSO,
  title={Crystal structure of enterotoxigenic Escherichia coli colonization factor CS6 reveals a novel type of functional assembly.},
  author={Saumendra P Roy and Mohammad Matiur Rahman and Xiao Di Yu and Minna T. Tuittila and Stefan D Knight and Anton V Zavialov},
  journal={Molecular microbiology},
  year={2012},
  volume={86 5},
  pages={1100-15}
}
Coli surface antigen 6 (CS6) is a widely expressed enterotoxigenic Escherichia coli (ETEC) colonization factor that mediates bacterial attachment to the small intestinal epithelium. CS6 is a polymer of two protein subunits CssA and CssB, which are secreted and assembled on the cell surface via the CssC/CssD chaperone usher (CU) pathway. Here, we present an atomic resolution model for the structure of CS6 based on the results of X-ray crystallographic, spectroscopic and biochemical studies, and… CONTINUE READING