Crystal structure of dimeric HIV-1 capsid protein

  title={Crystal structure of dimeric HIV-1 capsid protein},
  author={Cory Momany and Ladislau C. Kovari and Andrew J. Prongay and Walter Keller and Rossitza K. Gitti and Brian M. Lee and Alexander E. Gorbalenya and Liang Tong and Jan McClure and Lorna S. Ehrlich and Michael F Summers and Carol Carter and Michael G. Rossmann},
  journal={Nature Structural Biology},
X-ray diffraction analysis of a human immunodeficiency virus (HIV-1) capsid (CA) protein shows that each monomer within the dimer consists of seven α-helices, five of which are arranged in a coiled coil-like structure. Sequence assignments were made for two of the helices, and tentative connectivity of the remainder of the protein was confirmed by the recent solution structure of a monomeric N-terminal fragment. The C-terminal third of the protein is mostly disordered in the crystal. The… CONTINUE READING

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