Crystal structure of designed PX domain from cytokine-independent survival kinase and implications on evolution-based protein engineering.

Abstract

The Phox homology domain (PX domain) is a phosphoinositide-binding structural domain that is critical in mediating protein and cell membrane association and has been found in more than 100 eukaryotic proteins. The abundance of PX domains in nature offers an opportunity to redesign the protein using EvoDesign, a computational approach to design new sequences… (More)
DOI: 10.1016/j.jsb.2015.06.009

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10 Figures and Tables