Crystal structure of cytotoxin protein suilysin from Streptococcus suis

  title={Crystal structure of cytotoxin protein suilysin from Streptococcus suis},
  author={Lingfeng Xu and Bo Huang and Huamao Du and Xuejun Cai Zhang and Jian-guo Xu and Xue-mei Li and Zihe Rao},
  journal={Protein & Cell},
Cholesterol-dependent cytolysins (CDC) are pore forming toxins. A prototype of the CDC family members is perfringolysin O (PFO), which directly binds to the cell membrane enriched in cholesterol, causing cell lysis. However, an exception of this general observation is intermedilysin (ILY) of Streptococcus intermedius, which requires human CD59 as a receptor in addition to cholesterol for its hemolytic activity. A possible explanation of this functional difference is the conformational variation… CONTINUE READING


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PROCHECK: a program to check the stereochemical quality of protein structures

  • R. A. Laskowski, M. W. MacArthur, D. S. Moss, J. M. Thornton
  • J Appl Crystallogr
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