Crystal structure of cyclic Lys48-linked tetraubiquitin.


Lys48-linked polyubiquitin chains serve as a signal for protein degradation by 26S proteasomes through its Ile44 hydrophobic patches interactions. The individual ubiquitin units of each chain are conjugated through an isopeptide bond between Lys48 and the C-terminal Gly76 of the preceding units. The conformation of Lys48-linked tetraubiquitin has been shown… (More)
DOI: 10.1016/j.bbrc.2010.08.057


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@article{Satoh2010CrystalSO, title={Crystal structure of cyclic Lys48-linked tetraubiquitin.}, author={Tadashi Satoh and Eri Sakata and Shunsuke Yamamoto and Yoshiki Yamaguchi and Akira Sumiyoshi and Soichi Wakatsuki and Koichi Kato}, journal={Biochemical and biophysical research communications}, year={2010}, volume={400 3}, pages={329-33} }