Crystal structure of bile salt hydrolase from Lactobacillus salivarius.

  title={Crystal structure of bile salt hydrolase from Lactobacillus salivarius.},
  author={Fuzhou Xu and Fangfang Guo and Xiao Jian Hu and Jun Biao Lin},
  journal={Acta crystallographica. Section F, Structural biology communications},
  volume={72 Pt 5},
Bile salt hydrolase (BSH) is a gut-bacterial enzyme that negatively influences host fat digestion and energy harvesting. The BSH enzyme activity functions as a gateway reaction in the small intestine by the deconjugation of glycine-conjugated or taurine-conjugated bile acids. Extensive gut-microbiota studies have suggested that BSH is a key mechanistic microbiome target for the development of novel non-antibiotic food additives to improve animal feed production and for the design of new… CONTINUE READING
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