Crystal structure of an idiotype-anti-idiotype Fab complex.

  title={Crystal structure of an idiotype-anti-idiotype Fab complex.},
  author={Nenad Ban and Camila Escobar and Rom{\'a}n Garc{\'i}a and Karl W. Hasel and Joseph Day and A Greenwood and A. Mcpherson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={91 5},
Anti-idiotypic monoclonal antibody 409.5.3 is raised against an antibody that neutralizes feline infectious peritonitis virus. This antibody, used as an immunogen, elicits the production of anti-anti-idiotypic antibodies that in turn neutralize the virus. The crystal structure of the complex between anti-idiotypic Fab 409.5.3 and idiotypic Fab fragment of virus-neutralizing antibody has been solved by molecular replacement using real-space Patterson search and filtering by Patterson correlation… CONTINUE READING
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