Crystal structure of an archaeal Rad51 homologue in complex with a metatungstate inhibitor.


Archaeal RadAs are close homologues of eukaryal Rad51s ( approximately 40% sequence identities). These recombinases promote a hallmark strand exchange process between homologous single-stranded and double-stranded DNA substrates. This DNA-repairing function also plays a key role in cancer cells' resistance to chemo- and radiotherapy. Inhibition of the… (More)
DOI: 10.1021/bi900832t