Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus.

@article{Matsumiya2001CrystalSO,
  title={Crystal structure of an archaeal DNA sliding clamp: proliferating cell nuclear antigen from Pyrococcus furiosus.},
  author={Shigeki Matsumiya and Yoshizumi Ishino and Kosuke Morikawa},
  journal={Protein science : a publication of the Protein Society},
  year={2001},
  volume={10 1},
  pages={17-23}
}
The proliferating cell nuclear antigen (PCNA) is now recognized as one of the key proteins in DNA metabolic events because of its direct interactions with many proteins involved in important cellular processes. We have determined the crystal structure of PCNA from a hyperthermophilic archaeon, Pyrococcus furiosus (pfuPCNA), at 2.1 A resolution. pfuPCNA forms a toroidal, ring-shaped structure consisting of homotrimeric molecules, which is also observed in the PCNA crystals from human and yeast… CONTINUE READING
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