Crystal structure of an antifreeze polypeptide and its mechanistic implications

@article{Yang1988CrystalSO,
  title={Crystal structure of an antifreeze polypeptide and its mechanistic implications},
  author={Daniel S. Yang and Martin Sax and Avijit Chakrabartty and Choy Leong Hew},
  journal={Nature},
  year={1988},
  volume={333},
  pages={232-237}
}
The X-ray crystallographic structure of an antifreeze polypeptide from the fish winter flounder, has been determined at 2.5 Å by an analysis of the Patter son function. This is the first report of a polypeptide of this size that is a single α-helix. A proposed mechanism of antifreeze binding to ice surfaces is given which requires: first, that the dipole moment from the helical structure dictates the preferential alignment of the peptide to the c-axis of ice nuclei; second, amphiphilicity of… CONTINUE READING