Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex

  title={Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex},
  author={Debora Lika Makino and Marc Baumg{\"a}rtner and Elena Conti},
The exosome is the major 3′–5′ RNA-degradation complex in eukaryotes. The ubiquitous core of the yeast exosome (Exo-10) is formed by nine catalytically inert subunits (Exo-9) and a single active RNase, Rrp44. In the nucleus, the Exo-10 core recruits another nuclease, Rrp6. Here we crystallized an approximately 440-kilodalton complex of Saccharomyces cerevisiae Exo-10 bound to a carboxy-terminal region of Rrp6 and to an RNA duplex with a 3′-overhang of 31 ribonucleotides. The 2.8 Å resolution… CONTINUE READING
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