Crystal structure of an RNA bacteriophage coat protein–operator complex

@article{Valegrd1994CrystalSO,
  title={Crystal structure of an RNA bacteriophage coat protein–operator complex},
  author={Karin Valeg{\aa}rd and James B Murray and Peter G. Stockley and Nicola J Stonehouse and L. Liljas},
  journal={Nature},
  year={1994},
  volume={371},
  pages={623-626}
}
THE RNA bacteriophage MS2 is a convenient model system for the study of protein–RNA interactions. The MS2 coat protein achieves control of two distinct processes—sequence-specific RNA encapsidation and repression of replicase translation—by binding to an RNA stem–loop structure of 19 nucleotides containing the initiation codon of the replicase gene. The binding of a coat protein dimer to this hairpin shuts off synthesis of the viral replicase1, switching the viral replication cycle to virion… CONTINUE READING

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