Crystal structure of an ATPase-active form of Rad51 homolog from Methanococcus voltae. Insights into potassium dependence.

@article{Wu2005CrystalSO,
  title={Crystal structure of an ATPase-active form of Rad51 homolog from Methanococcus voltae. Insights into potassium dependence.},
  author={Yan Wu and Xinguo Qian and Yujiong He and Ignace A Moya and Yu Bing Luo},
  journal={The Journal of biological chemistry},
  year={2005},
  volume={280 1},
  pages={722-8}
}
Homologous gene recombination is crucial for the repair of DNA. A superfamily of recombinases facilitate a central strand exchange reaction in the repair process. This reaction is initiated by coating single-stranded DNA (ssDNA) with recombinases in the presence of ATP and Mg(2+) co-factors to form helical nucleoprotein filaments with elevated ATPase and strand invasion activities. At the amino acid sequence level, archaeal RadA and Rad51 and eukaryal Rad51 and meiosis-specific DMC1 form a… CONTINUE READING

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