Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.

@article{Mnez2008CrystalSO,
  title={Crystal structure of a ternary complex between human prostate-specific antigen, its substrate acyl intermediate and an activating antibody.},
  author={Ren{\'e}e M{\'e}nez and Sandrine Michel and Bruno H. Muller and Marc Bossus and Fr{\'e}d{\'e}ric Ducancel and Colette Jolivet-Reynaud and Enrico A Stura},
  journal={Journal of molecular biology},
  year={2008},
  volume={376 4},
  pages={1021-33}
}
Human prostate-specific antigen (PSA or KLK3) is an important marker for the diagnosis and management of prostate cancer. This is an androgen-regulated glycoprotein of the kallikrein-related protease family secreted by prostatic epithelial cells. Its physiological function is to cleave semenogelins in the seminal coagulum and its enzymatic activity is strongly modulated by zinc ions. Here we present the first crystal structure of human PSA in complex with monoclonal antibody (mAb) 8G8F5 that… CONTINUE READING