Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 Å resolution

@article{Leahy1992CrystalSO,
  title={Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 {\AA} resolution},
  author={Daniel J. Leahy and Richard Axel and Wayne A. Hendrickson},
  journal={Cell},
  year={1992},
  volume={68},
  pages={1145-1162}
}
A secreted fragment of the extracellular portion of human CD8 alpha has been expressed in CHO cells, and a deglycosylated and proteolyzed form of this fragment has been crystallized. We report here the crystal structure of this fragment as refined at 2.6 A resolution. The structure was solved by molecular replacement using a superposition of ten variable domains from immunoglobulin light chains as the search model. Only the N-terminal 114 amino acids of CD8 alpha are visible in the electron… Expand
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