Crystal structure of a soluble cleaved HIV-1 envelope trimer.

  title={Crystal structure of a soluble cleaved HIV-1 envelope trimer.},
  author={Jean-Philippe Julien and Albert Cupo and Devin Sok and Robyn L Stanfield and Dmitry Lyumkis and Marc C. Deller and Per-Johan Klasse and Dennis R. Burton and Rogier W. Sanders and John P. Moore and Andrew B. Ward and Ian A. Wilson},
  volume={342 6165},
HIV-1 entry into CD4(+) target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4.7 angstroms of a soluble, cleaved Env trimer that is stabilized and antigenically near-native (termed the BG505 SOSIP.664 gp140 trimer) in complex with a potent broadly neutralizing antibody, PGT122. The structure shows a prefusion state of gp41, the interaction between the component gp120 and gp41… CONTINUE READING
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