Crystal structure of a soluble cleaved HIV-1 envelope trimer.

@article{Julien2013CrystalSO,
  title={Crystal structure of a soluble cleaved HIV-1 envelope trimer.},
  author={Jean-Philippe Julien and Albert Cupo and Devin Sok and Robyn L Stanfield and Dmitry Lyumkis and Marc C. Deller and Per-Johan Klasse and Dennis R. Burton and Rogier W. Sanders and John P. Moore and Andrew B. Ward and Ian A. Wilson},
  journal={Science},
  year={2013},
  volume={342 6165},
  pages={1477-83}
}
HIV-1 entry into CD4(+) target cells is mediated by cleaved envelope glycoprotein (Env) trimers that have been challenging to characterize structurally. Here, we describe the crystal structure at 4.7 angstroms of a soluble, cleaved Env trimer that is stabilized and antigenically near-native (termed the BG505 SOSIP.664 gp140 trimer) in complex with a potent broadly neutralizing antibody, PGT122. The structure shows a prefusion state of gp41, the interaction between the component gp120 and gp41… CONTINUE READING
Highly Influential
This paper has highly influenced 25 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 231 extracted citations

HIV broadly neutralizing antibody targets.

Current opinion in HIV and AIDS • 2015
View 8 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…