Crystal structure of a phospholipase D family member

@article{Stuckey1999CrystalSO,
  title={Crystal structure of a phospholipase D family member},
  author={Jeanne A. Stuckey and Jack E. Dixon},
  journal={Nature Structural Biology},
  year={1999},
  volume={6},
  pages={278-284}
}
The first crystal structure of a phospholipase D (PLD) family member has been determined at 2.0 Å resolution. The PLD superfamily is defined by a common sequence motif, HxK(x)4D(x)6GSxN, and includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. The crystal structure suggests that residues from two sequence motifs form a single active site. A histidine residue from one motif acts as a nucleophile in the… CONTINUE READING

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