Crystal structure of a phage Twort group I ribozyme–product complex

Abstract

Group I introns are catalytic RNAs capable of orchestrating two sequential phosphotransesterification reactions that result in self-splicing. To understand how the group I intron active site facilitates catalysis, we have solved the structure of an active ribozyme derived from the orf142-I2 intron from phage Twort bound to a four-nucleotide product RNA at a… (More)
DOI: 10.1038/nsmb868

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