Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases

@article{Ha2005CrystalSO,
  title={Crystal structure of a junction between B-DNA and Z-DNA reveals two extruded bases},
  author={S. Ha and K. Lowenhaupt and A. Rich and Yang-Gyun Kim and K. Kim},
  journal={Nature},
  year={2005},
  volume={437},
  pages={1183-1186}
}
  • S. Ha, K. Lowenhaupt, +2 authors K. Kim
  • Published 2005
  • Medicine, Chemistry
  • Nature
  • Left-handed Z-DNA is a higher-energy form of the double helix, stabilized by negative supercoiling generated by transcription or unwrapping nucleosomes. Regions near the transcription start site frequently contain sequence motifs favourable for forming Z-DNA, and formation of Z-DNA near the promoter region stimulates transcription. Z-DNA is also stabilized by specific protein binding; several proteins have been identified with low nanomolar binding constants. Z-DNA occurs in a dynamic state… CONTINUE READING

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