Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer.

@article{Kouvatsos2016CrystalSO,
  title={Crystal structure of a human neuronal nAChR extracellular domain in pentameric assembly: Ligand-bound α2 homopentamer.},
  author={Nikolaos Kouvatsos and Petros Giastas and Dafni Chroni-Tzartou and Cornelia Poulopoulou and Socrates J Tzartos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 34},
  pages={9635-40}
}
In this study we report the X-ray crystal structure of the extracellular domain (ECD) of the human neuronal α2 nicotinic acetylcholine receptor (nAChR) subunit in complex with the agonist epibatidine at 3.2 Å. Interestingly, α2 was crystallized as a pentamer, revealing the intersubunit interactions in a wild type neuronal nAChR ECD and the full ligand… CONTINUE READING