Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 Å resolution

@article{Chon2005CrystalSO,
  title={Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 {\AA} resolution},
  author={H. Chon and H. Matsumura and Y. Koga and K. Takano and S. Kanaya},
  journal={Proteins: Structure},
  year={2005},
  volume={61}
}
  • H. Chon, H. Matsumura, +2 authors S. Kanaya
  • Published 2005
  • Chemistry, Medicine
  • Proteins: Structure
  • Introduction. Kynurenine aminotransferase (KAT; EC. 2.6.1.7) is an enzyme that catalyzes the irreversible transamination of L-kynurenine (L-Kyn) to produce kynurenic acid (KA). L-Kyn is a major metabolite in the degradation pathway of tryptophan, and KA acts as an endogenous antagonist of all three ionotropic excitatory amino acid receptors in the central nervous system. Enormous attention has recently been paid to structural and functional studies of KAT, because alteration in the endogenous… CONTINUE READING
    15 Citations

    Topics from this paper

    Crystal Structure of Human Kynurenine Aminotransferase II*
    • 42
    • PDF
    Structural and mechanistic insights into the kynurenine aminotransferase-mediated excretion of kynurenic acid.
    • 3
    Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 Å Resolution
    • 13
    • PDF
    Structure, expression, and function of kynurenine aminotransferases in human and rodent brains
    • 155
    Biochemical and Structural Properties of Mouse Kynurenine Aminotransferase III
    • 65
    • PDF
    Curiosity to kill the KAT (kynurenine aminotransferase): structural insights into brain kynurenic acid synthesis.
    • 40

    References

    SHOWING 1-10 OF 39 REFERENCES
    Overproduction and preliminary crystallographic study of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3.
    • H. Chon, H. Matsumura, +4 authors S. Kanaya
    • Biology, Medicine
    • Acta crystallographica. Section F, Structural biology and crystallization communications
    • 2005
    • 4
    Crystal Structure of Human Kynurenine Aminotransferase I*
    • 38
    • PDF
    Characterization of rat brain kynurenine aminotransferases I and II
    • 214
    Two kynurenine aminotransferases in human brain
    • 153
    Crystal Structures of Glutamine:Phenylpyruvate Aminotransferase from Thermus thermophilus HB8
    • 24
    • PDF
    Kynurenine metabolism in Alzheimer's disease
    • 191