• DOI:10.1002/prot.20614
Corpus ID: 35477005

Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 Å resolution

@article{Chon2005CrystalSO,
  title={Crystal structure of a human kynurenine aminotransferase II homologue from Pyrococcus horikoshii OT3 at 2.20 {\AA} resolution},
  author={H. Chon and H. Matsumura and Y. Koga and K. Takano and S. Kanaya},
  journal={Proteins: Structure},
  year={2005},
  volume={61}
}

H. Chon, H. Matsumura, +2 authors S. Kanaya

Published 2005

Chemistry, Medicine

Proteins: Structure

Introduction. Kynurenine aminotransferase (KAT; EC. 2.6.1.7) is an enzyme that catalyzes the irreversible transamination of L-kynurenine (L-Kyn) to produce kynurenic acid (KA). L-Kyn is a major metabolite in the degradation pathway of tryptophan, and KA acts as an endogenous antagonist of all three ionotropic excitatory amino acid receptors in the central nervous system. Enormous attention has recently been paid to structural and functional studies of KAT, because alteration in the endogenous… CONTINUE READING

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