Crystal structure of a human TATA box-binding protein/TATA element complex.

@article{Nikolov1996CrystalSO,
  title={Crystal structure of a human TATA box-binding protein/TATA element complex.},
  author={Dimitar B. Nikolov and Huaming Chen and Elaine D. Halay and Aaron Hoffman and Robert G Roeder and Stephen K. Burley},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1996},
  volume={93 10},
  pages={4862-7}
}
The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms… CONTINUE READING