Crystal structure of a eukaryotic group II intron lariat

@inproceedings{Robart2014CrystalSO,
  title={Crystal structure of a eukaryotic group II intron lariat},
  author={Aaron R. Robart and Russell T. Chan and Jessica K. Peters and Kanagalaghatta R. Rajashankar and Navtej Toor},
  booktitle={Nature},
  year={2014}
}
The formation of branched lariat RNA is an evolutionarily conserved feature of splicing reactions for both group II and spliceosomal introns. The lariat is important for the fidelity of 5′ splice-site selection and consists of a 2′-5′ phosphodiester bond between a bulged adenosine and the 5′ end of the intron. To gain insight into this ubiquitous intramolecular linkage, we determined the crystal structure of a eukaryotic group IIB intron in the lariat form at 3.7 Å. This revealed that two… CONTINUE READING
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