Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody.

@article{Li2008CrystalSO,
  title={Crystal structure of a dimerized cockroach allergen Bla g 2 complexed with a monoclonal antibody.},
  author={Mi Li and Alla Gustchina and Jerry N Alexandratos and Alexander Wlodawer and Sabina Wuenschmann and Christopher L. Kepley and Martin D. Chapman and Anna Pom{\'e}s},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 33},
  pages={22806-14}
}
The crystal structure of a 1:1 complex between the German cockroach allergen Bla g 2 and the Fab' fragment of a monoclonal antibody 7C11 was solved at 2.8-angstroms resolution. Bla g 2 binds to the antibody through four loops that include residues 60-70, 83-86, 98-100, and 129-132. Cation-pi interactions exist between Lys-65, Arg-83, and Lys-132 in Bla g 2 and several tyrosines in 7C11. In the complex with Fab', Bla g 2 forms a dimer, which is stabilized by a quasi-four-helix bundle comprised… CONTINUE READING

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Antibody Complex of Bla g 2 22814 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

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