Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.

@article{Liu2007CrystalSO,
  title={Crystal structure of a biosynthetic sulfo-hirudin complexed to thrombin.},
  author={Chang C Liu and Eric M Brustad and Wenshe R Liu and Peter G. Schultz},
  journal={Journal of the American Chemical Society},
  year={2007},
  volume={129 35},
  pages={10648-9}
}
The leech-derived protein hirudin is the most potent naturally occurring direct thrombin inhibitor (DTI) known and is used clinically as an anticoagulant. 1,2 The natural form of hirudin (sulfohirudin) exhibits a Ki toward thrombin of approximately 25 fM, and the therapeutic form of the protein generated recombinantly in E. coli or yeast exhibits a K i of… CONTINUE READING