Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution

Abstract

DNA polymerases change their specificity for nucleotide substrates with each catalytic cycle, while achieving error frequencies in the range of 10 −5to 10−6. Here we present a 2.2 Å crystal structure of the replicative DNA polymerase from bacteriophage T7 complexed with a primer–template and a nucleoside triphosphate in the polymerase active site. The… (More)
DOI: 10.1038/34593

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