Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters

@article{Yamashita2005CrystalSO,
  title={Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters},
  author={Atsuko Yamashita and Satinder K. Singh and Toshimitsu Kawate and Yan Jin and Eric Gouaux},
  journal={Nature},
  year={2005},
  volume={437},
  pages={215-223}
}
Na+/Cl--dependent transporters terminate synaptic transmission by using electrochemical gradients to drive the uptake of neurotransmitters, including the biogenic amines, from the synapse to the cytoplasm of neurons and glia. These transporters are the targets of therapeutic and illicit compounds, and their dysfunction has been implicated in multiple diseases of the nervous system. Here we present the crystal structure of a bacterial homologue of these transporters from Aquifex aeolicus, in… 

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