Crystal structure of a Src-homology 3 (SH3) domain

  title={Crystal structure of a Src-homology 3 (SH3) domain},
  author={Andrea Musacchio and Martin E M Noble and Richard A. Pauptit and Rik Wierenga and Matti Saraste},
THE Src-homologous SH3 domain is a small domain present in a large number of proteins that are involved in signal transduction, such as the Src protein tyrosine kinase, or in membrane-cyto-skeleton interactions, but the function of SH3 is still unknown (reviewed in refs 1–3). Here we report the three-dimensional struc-ture at 1.8 Å resolution of the SH3 domain of the cytoskeletal protein spectrin expressed in Escherichia coli. The domain is a compact β-barrel made of five antiparallel β-strands… CONTINUE READING

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