Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 Å resolution

@article{Sutton1998CrystalSO,
  title={Crystal structure of a SNARE complex involved in synaptic exocytosis at 2.4 {\AA} resolution},
  author={R B Sutton and Dirk Fasshauer and Reinhard Jahn and Axel T. Brunger},
  journal={Nature},
  year={1998},
  volume={395},
  pages={347-353}
}
The evolutionarily conserved SNARE proteins and their complexes are involved in the fusion of vesicles with their target membranes; however, the overall organization and structural details of these complexes are unknown. Here we report the X-ray crystal structure at 2.4 Å resolution of a core synaptic fusion complex containing syntaxin-1A, synaptobrevin-II and SNAP-25B. The structure reveals a highly twisted and parallel four-helix bundle that differs from the bundles described for the… 

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Dynamic Relationship of the SNARE Complex with a Membrane.

Dynamic structure of lipid-bound synaptobrevin suggests a nucleation-propagation mechanism for trans-SNARE complex formation

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The ionic layer is required for efficient dissociation of the SNARE complex by α-SNAP and NSF

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Structural principles of SNARE complex recognition by the AAA+ protein NSF

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