# Crystal structure of a GA protein βγdimer at 2.1 Å resolution

@article{Sondek1996CrystalSO,
title={Crystal structure of a GA protein $\beta$$\gamma$dimer at 2.1 {\AA} resolution},
author={John Sondek and Andrew Bohm and David G. Lambright and Heidi E. Hamm and Paul B. Sigler},
journal={Nature},
year={1996},
volume={379},
pages={369-374}
}
• Published 25 January 1996
• Chemistry, Biology
• Nature
MANY signalling cascades use seven-helical transmembrane receptors coupled to heterotrimeric G proteins (Gαβγ) to convert extracellular signals into intracellular responses1. Upon nucleotide exchange catalysed by activated receptors, heterotrimers dissociate into GTP-bound Gα subunits and Gβγ dimers, either of which can modulate many downstream effectors2,3. Here we use multiwavelength anomalous diffraction data to solve the crystal structure of the βγ dimer of the G protein transducin. The…
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