Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.

@article{Lee2011CrystalSO,
  title={Crystal structure of a BCL-W domain-swapped dimer: implications for the function of BCL-2 family proteins.},
  author={Erinna F. Lee and Grant Dewson and Brian J Smith and Marco Evangelista and Anne Pettikiriarachchi and Con Dogovski and Matthew A. Perugini and Peter M. Colman and Walter Douglas Fairlie},
  journal={Structure},
  year={2011},
  volume={19 10},
  pages={1467-76}
}
The prosurvival and proapoptotic proteins of the BCL-2 family share a similar three-dimensional fold despite their opposing functions. However, many biochemical studies highlight the requirement for conformational changes for the functioning of both types of proteins, although structural data to support such changes remain elusive. Here, we describe the X-ray structure of dimeric BCL-W that reveals a major conformational change involving helices α3 and α4 hinging away from the core of the… CONTINUE READING