Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor

@article{Lei2016CrystalSO,
  title={Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor},
  author={Jian Lei and Guido Hansen and Christoph Nitsche and Christian D. Klein and L Zhang and Rolf Hilgenfeld},
  journal={Science},
  year={2016},
  volume={353},
  pages={503-505}
}
The ongoing Zika virus (ZIKV) outbreak is linked to severe neurological disorders. ZIKV relies on its NS2B/NS3 protease for polyprotein processing; hence, this enzyme is an attractive drug target. The 2.7 angstrom; crystal structure of ZIKV protease in complex with a peptidomimetic boronic acid inhibitor reveals a cyclic diester between the boronic acid and glycerol. The P2 4-aminomethylphenylalanine moiety of the inhibitor forms a salt-bridge with the nonconserved Asp83 of NS2B; ion-pairing… CONTINUE READING
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