Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA

@article{Losey2006CrystalSO,
  title={Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA},
  author={Heather C. Losey and Alexander J. Ruthenburg and Gregory L. Verdine},
  journal={Nature Structural \&Molecular Biology},
  year={2006},
  volume={13},
  pages={153-159}
}
Bacterial tRNA adenosine deaminases (TadAs) catalyze the hydrolytic deamination of adenosine to inosine at the wobble position of tRNAArg2, a process that enables this single tRNA to recognize three different arginine codons in mRNA. In addition, inosine is also introduced at the wobble position of multiple eukaryotic tRNAs. The genes encoding these deaminases are essential in bacteria and yeast, demonstrating the importance of their biological activity. Here we report the crystallization and… 

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