Crystal structure of Staphylococcus aureus peptidyl-tRNA hydrolase at a 2.25 Å resolution.


Peptidyl-tRNA hydrolase (Pth) catalyzes the release of tRNA to relieve peptidyl-tRNA accumulation. Because Pth activity is essential for the viability of bacteria, Pth is regarded as a promising target for the discovery of new antimicrobial agents. Here, the structure of Pth from the Gram-positive bacterium Staphylococcus aureus (SaPth) was solved by X-ray… (More)
DOI: 10.1093/abbs/gmv114

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