Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism.

@article{Kavanagh2002CrystalSO,
  title={Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism.},
  author={Kathryn L. Kavanagh and Mario Klimacek and Bernd Nidetzky and David K Wilson},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 45},
  pages={43433-42}
}
Long-chain mannitol dehydrogenases are secondary alcohol dehydrogenases that are of wide interest because of their involvement in metabolism and potential applications in agriculture, medicine, and industry. They differ from other alcohol and polyol dehydrogenases because they do not contain a conserved tyrosine and are not dependent on Zn(2+) or other metal cofactors. The structures of the long-chain mannitol 2-dehydrogenase (54 kDa) from Pseudomonas fluorescens in a binary complex with NAD… CONTINUE READING

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