Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.

@article{CohenGonsaud2002CrystalSO,
  title={Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.},
  author={Martin Cohen-Gonsaud and St{\'e}phanie Ducasse and François Hoh and Didier Zerbib and Gilles Labesse and Anna{\"i}k Qu{\'e}mard},
  journal={Journal of molecular biology},
  year={2002},
  volume={320 2},
  pages={249-61}
}
The fatty acid elongation system FAS-II is involved in the biosynthesis of mycolic acids, which are major and specific long-chain fatty acids of the cell envelope of Mycobacterium tuberculosis and other mycobacteria, including Mycobacterium smegmatis. The protein MabA, also named FabG1, has been shown recently to be part of FAS-II and to catalyse the NADPH-specific reduction of long chain beta-ketoacyl derivatives. This activity corresponds to the second step of an FAS-II elongation round. FAS… CONTINUE READING