Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.

@article{Mochalkin2008CrystalSO,
  title={Crystal structure of LpxC from Pseudomonas aeruginosa complexed with the potent BB-78485 inhibitor.},
  author={Igor Mochalkin and John D. Knafels and Sandra A Lightle},
  journal={Protein science : a publication of the Protein Society},
  year={2008},
  volume={17 3},
  pages={450-7}
}
The cell wall in Gram-negative bacteria is surrounded by an outer membrane comprised of charged lipopolysaccharide (LPS) molecules that prevent entry of hydrophobic agents into the cell and protect the bacterium from many antibiotics. The hydrophobic anchor of LPS is lipid A, the biosynthesis of which is essential for bacterial growth and viability. UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase (LpxC) is an essential zinc-dependant enzyme that catalyzes the conversion of UDP-3… CONTINUE READING
10 Citations
43 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 43 references

Similar Papers

Loading similar papers…