Crystal structure of Hop2–Mnd1 and mechanistic insights into its role in meiotic recombination

@inproceedings{Kang2015CrystalSO,
  title={Crystal structure of Hop2–Mnd1 and mechanistic insights into its role in meiotic recombination},
  author={Hyun-Ah Kang and Ho-chul Shin and Alexandra-Styliani Kalantzi and Christopher P. Toseland and Hyun-Min Kim and Stephan Gruber and Matteo Dal Peraro and Byung-Ha Oh},
  booktitle={Nucleic acids research},
  year={2015}
}
In meiotic DNA recombination, the Hop2-Mnd1 complex promotes Dmc1-mediated single-stranded DNA (ssDNA) invasion into homologous chromosomes to form a synaptic complex by a yet-unclear mechanism. Here, the crystal structure of Hop2-Mnd1 reveals that it forms a curved rod-like structure consisting of three leucine zippers and two kinked junctions. One end of the rod is linked to two juxtaposed winged-helix domains, and the other end is capped by extra α-helices to form a helical bundle-like… CONTINUE READING
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