Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing

@article{Klabunde1998CrystalSO,
  title={Crystal structure of GyrA intein from Mycobacterium xenopi reveals structural basis of protein splicing},
  author={Thomas Klabunde and Sujata Pandit Sharma and Amalio Telenti and William Robert Jacobs and James C. Sacchettini},
  journal={Nature Structural Biology},
  year={1998},
  volume={5},
  pages={31-36}
}
Several genes from prokaryotes and lower eukaryotes have been found to contain an in-frame open reading frame, which encodes for an internal protein (intein). Post-translationally, the internal polypeptide auto-splices and ligates the external sequences to yield a functional external protein (extein) and an intein. Most, but not all inteins, contain, apart from a splicing domain, a separate endonucleolytic domain that enables them to maintain their presence by a homing mechanism. We report here… CONTINUE READING

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