Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.

@article{Xiao1999CrystalSO,
  title={Crystal structure of Escherichia coli uracil DNA glycosylase and its complexes with uracil and glycerol: structure and glycosylase mechanism revisited.},
  author={Gaoyi Xiao and Maria Tordova and J. Jagadeesh and Alexander C. Drohat and James T Stivers and Gary L Gilliland},
  journal={Proteins},
  year={1999},
  volume={35 1},
  pages={13-24}
}
The DNA repair enzyme uracil DNA glycosylase (UDG) catalyzes the hydrolysis of premutagenic uracil residues from single-stranded or duplex DNA, producing free uracil and abasic DNA. Here we report the high-resolution crystal structures of free UDG from Escherichia coli strain B (1.60 A), its complex with uracil (1.50 A), and a second active-site complex… CONTINUE READING