Crystal structure of Escherichia coli pyruvate kinase type I: molecular basis of the allosteric transition.

Abstract

BACKGROUND Pyruvate kinase (PK) plays a major role in the regulation of glycolysis. Its catalytic activity is controlled by the substrate phosphoenolpyruvate and by one or more allosteric effectors. The crystal structures of the non-allosteric PKs from cat and rabbit muscle are known. We have determined the three-dimensional structure of the allosteric type… (More)

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